Sunday, September 21, 2008
L-arginine, the Trojan Horse
An article to be published in the proceedings of the National Academy of Sciences shortly will present some research from Stanford University on the use of l-arginine to help fight resistant disease.
The l-arginine surrounds the antibiotic chosen, allowing this complex to get past the membrane pump that encloses the resistant cells. Eight l-arginine molecules surrounded Taxol, the drug used against ovarian cancer in mice.
L-arginine is common in metabolism throughout the body and therefore allowing the resistant cell to allow entry of this complex much like it was a “Trojan Horse”. This in effect “disguised” the Taxol allowing the entry into the resistant cell.
Taxol was used in this study but the authors felt other medications could be used as well.