Cardiometabolic Risk of Antipsychotic Medications in Youth JAMA Oct 28, 2009 Pg.1765-1773
Many of us, who see people with metabolic syndrome, particularly in young people, have been startled by the sharp rise in new patients who seem to have been started on antipsychotic medication. Many others who are no longer considered “youths” have similar problems.
The Cardiometabolic Syndrome (AKA METABOLIC SYNDROME, DYSMETABOLIC SYNDRONE, and SYNDROME X) is now regarded to be much more of a clinical problem than just prediabetes since the pre-atherosclerotic component is much worse and more dangerous for early death than previously thought.
The weight changes were most striking. 10% to 36% transitioned to overweight or obese within 11 weeks. These changes were not felt to be due worsening psychiatric disorders. The concern is that youths with this weight and metabolic status will accelerate the cardiometabolic syndrome and its complications. The medications involved in this study include,
Risperidone (http://www.medicinenet.com/risperidone/article.htm)
Quetiapine (Seroquel) http://www.seroquelxr.com/index.aspx?source=828&utm_source=google&utm_medium=cpc&utm_content=brandxrdtc&utm_campaign=SQLJUN09&WT.mc_id=SQL0209GOOPSDTCB&gclid=CPSUrs-_650CFRgbawodUgQ6LA
Abilify (Aripiprazole) http://www.abilify.com/
Zyprexa http://www.medicinenet.com/olanzapine/article.htm
To trade a serious psychiatric illness for another serious chronic disease is quite a decision. It is something to seriously think about.
It is looked upon as a drug that can precipitate Diabetes type 2. If you have type 1 you can also add insulin resistance and abdominal fat to your problems.
Dr. Joe
Monday, November 02, 2009
Subscribe to:
Post Comments (Atom)
1 comments:
I have had type 1 DM for 41 years. From 1994 to 2007 I was on Risperdal which was prescribed for depression (not psychosis). I am not overweight and never have been and all my labs were picture perfect except for my A1C which was in the 8s. In 2005, in spite of lipids being excellent, weight being slightly underweight and diet being good (vegetarian) and good exercise, I had a cardiovascular event and had severe blockages in 2 arteries and 60% in 2 others. I was under tremendous stress at the time, feared for my life. I always thought the stress caused the heart attack, but now wonder about the role of Risperdal. I stopped it in 2007.
Post a Comment