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Importance of low-Grade Albuminuria

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Importance of low-Grade Albuminuria

The importance of low grade albuminuria is changing the world of understanding of the complications of diabetes.

Throughout my career I believed and understood from all my teachers that chronic diabetes renal disease begins in kidneys.

Cardiovascular disease was typically thought to originate and to progress as a separate entity. As these things are looked at today, it seems that these beliefs are entirely reversed. It is cardiovascular disease that is beginning and the kidney is best thought of as a ball of blood vessels, large and small, that get included in the vessels undergoing accelerated atherosclerosis so characteristic of diabetes.

The urinary albumen excretion is now accepted as an important marker for developing cardiovascular disease. The traditional upper limit of protein in the urine is 30 milligrams per deciliter. The levels above this but lower than a gram is microalbuminuria.

This association of protein excretion and cardiovascular disease is independent of kidney function. The treatment in my office is valsartan and an l-arginine complex ProArgi9 plus® that seems to quickly reverse this clinical situation.

Mayo Clinic Proc. July 2008 ;(7):806-812

My Story

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Many people have emailed in to ask why I am so hot about l-arginine. I wrote a book about this called the “Uncommon Doctor” which you are welcome to buy, but let me summarize it.

At age 37 I had a CT scan of my abdomen to check out a vague abdominal pain. We saw no abnormalities except, as the radiologist said, “You have the arteries of an 80 year old man”.

My father had his first stroke, the big one that never allowed him to work again, at age 42 so I figured I was in the gun sight for my own vascular tragedy.

I was desperate to find something that worked. John Farquhar in preventative medicine at Stanford was my first stop – he doesn’t recall our meeting – but each time I see him I thank him for saving my life.

The real attack began when I started working with Victor Dzau and John Cook using l-arginine to reverse atherosclerosis. This was in the Division of Cardiovascular Research and allowed me to start very small amounts of l-arginine, with the idea that although the appropriate dose was not known, you have to start somewhere.

I had been very familiar with l-arginine and had used in for endocrine testing and research both in my first fellowship at Henry Ford Hospital and the second at UCSF. I even tried to see if we could use it orally for growth hormone and insulin testing. I always joke that if I had been smart enough I would have won the Nobel Prize in Medicine in 1998! It’s a thought anyway.

As you might guess, I became a student of l-arginine. I read all that the three Nobel Prize winners published and constantly strived to make whatever product I was using better. I tried to get 3 different pharmaceutical firms interested in the retail manufacture and distribution of the product but who wants to have a product they cannot patent?

I started myself and all my patients on l-arginine in 1991 and gradually improved the product. I never believed that I could reverse the atherosclerosis, all that calcified plaque, that concrete in my arteries.

Then I had another CT scan of my abdomen. “How did you do this?” the radiologist shouted at me. I told him but he, like me, was befuddled. “It’s impossible” I thought to myself. How can you get rid of the concrete lining the arteries? It’s magic!

With time and much study I realized that it could be done and I was doing this on all my patients as well. 80% of my patients at that time had diabetes and we had been in the sad place where we were referring 30% for cardiac problems until 1991. Now we have not referred any patients or admitted any patients in 17 years.

I turned to Network marketing, social networking, to get the product I needed for myself and my patients. I had no idea that U-Tube was a new social phenomenon that sprang from the concept of Network marketing nor did I realize the quality of the products was as good as any pharmaceutical company until I had toured Synergy.

Now I can bring together all that I need for my arteries and work on continuing the development of what is now the best antiaging product around. ProArgi 9 plus (how to purchase) fulfills all that I hoped for and will look for in the future.

This is my story and my time of a moment of strategic health. You need not be terrified of what is ahead for you because now the path is clear and safe. It’s your time.

L-arginine, the Trojan Horse

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An article to be published in the proceedings of the National Academy of Sciences shortly will present some research from Stanford University on the use of l-arginine to help fight resistant disease.

The l-arginine surrounds the antibiotic chosen, allowing this complex to get past the membrane pump that encloses the resistant cells. Eight l-arginine molecules surrounded Taxol, the drug used against ovarian cancer in mice.

L-arginine is common in metabolism throughout the body and therefore allowing the resistant cell to allow entry of this complex much like it was a “Trojan Horse”. This in effect “disguised” the Taxol allowing the entry into the resistant cell.

Taxol was used in this study but the authors felt other medications could be used as well.

Nitric Oxide and Cancer 2.2008

This is probably unintelligible to most of you but this is a most important and current review on how l-arginine when use in large amounts can have a positive effect on multiple cancers.

I week ago I discussed parts of this with reference on how l-arginine works in different ways in different cancers and this abstract/paper expands on this theme.

The paper has not been printed yet but the references will probably lengthy. All this will need a great deal of further testing and clinical studies to figure out ultimate solutions, but look at the range of cancers addressed in this work.

It’s your time.

Dr. Joe

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8 Reasons Why Physicians Should Use Arginine

Anti-aging benefits. Promotes release of human growth hormone (hgh)

Reduces cholesterol and plaque formation

Great tasting

Improves memory function

Nitric oxide aids in keeping blood vessels elastic. Improves circulation.

Infection killer. Increases immune system, decreases inflammation.

Nutritional supplement. Quick and easy.

Energizing. Boosts energy levels.

Heart Enlargement

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Intro to the Insane Protocol

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Click here to see the Insane Protocol.

Antioxidants and l-arginine

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Diabetic Neuropathy

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Coronary Calcium Count

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Coronary Calcium Count

The New England Journal of Medicine March 27, 2008 had a paper that demonstrated the usefulness of counting calcium in the coronary (heart) arteries as a predictor of heart disease in four different ethnic groups. Caucasians, Blacks, Hispanics and Chinese all had the same responses to the observations.

A doubling of the calcium scores increased the risk of heart attack from 18 to 39% compared to those who had zero calcium in the arteries.

They concluded that any ethnic group can use this modality to asses their risk of heart disease and maybe they should.

Why We Age

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Why we age (Text Summary)
The normal process of cells burning fuel leads to aging then to disease and disability. Metabolically we are all on fire.

It begins with the metabolic syndrome that proceeds along the three pronged path to cardiovascular disease, Alzheimer’s disease and diabetes.

Oxidative damage is the black beast of our decline and its accomplice is inflammation. First it is the oxidative stress and then the cytokines and free radicals spearhead the decline of the body called aging and disease.

These terms will be familiar to you as you will pull out all the antiaging therapies that are becoming familiar. Complicated to be sure but the understanding allows you and I to prioritize the attack on entire aging process. We have all learned these processes in pieces. Diabetes first, or perhaps cardiovascular disease but ever stalked by the specter of Alzheimer’s disease.

That’s why I start with l-arginine first since 75-85% of the aging process begins with cardiovascular disease. Proagi9 plus has many of the additional anti-aging components that makes the anti-aging attack so strong. Not just a frontal attack on aging but a splendid quenching of the firers that burn us out too soon, too unevenly. The Biology of Human Longevity. – Caleb Finch Academic, Amsterdam, 2007

TDZs and Cardiovascular Outcomes

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Text Summary
Avandia and Actos have been individually accused of being associated with increased cardiovascular disease. This study involves 12,491 patients 66 years old or older who were taking these drugs and compared them to patients taking one or more hypoglycemic agents.

The study covered a medium of 3.8 years included data from Ontario.

12,491 were admitted to the hospital for congestive heart failure.
12,578 had a heart attack
30,265 died

This is about 4 times the cardiovascular problems of those taking other combination oral hypoglycemic agents.

We virtually have gone in my office for 18 years with only a rare case of these problems. I attribute this success to the l-argi9 plus and the weaker but successful other l-arginine products used previously.

How I Approach Type 1

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Diabetes and l-arginine #2

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Diabetes and l-argine

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Coronary Artery Calcium - Mayo Clinic

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Banked Blood Lacks Nitric Oxide

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Fire Fighters and Heart Disease

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My Brother's MRSA

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Intermittent Claudication

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Oxidative Stress and Free Radicals

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L-arginine and cancer

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How to Change L-Arginine Sources

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New l-arginine Product

We have settled into our new home in Palo Alto. In August we will be holding an OPEN HOUSE, look soon for a special invitation. This letter also serves to inform everyone that effective immediately we are we are not offering Argenix or CardioCocktail in our offices. If you wish to change, cancel or modify any existing orders you can reach our staff at (650) 566-9810 ext. #107 or orders@endocrinemetabolic.com. I have resigned from ForMor International on May 1, 2007 as their consultant.

As you know I am always looking for innovative ways to assist all of you with the newest cutting edge products for your health. I am excited to announce that I have accepted the position of Assistant Medical Director of Synergy Worldwide. Synergy is a wholly owned subsidiary of Nature’s Sunshine. Nature's Sunshine is a 34-year-old, publicly traded, debt-free giant in the herbal health industry. NSP does hundreds of millions of dollars of business annually. They are open for business internationally in 13 countries. We are working together to introduce new advancements in strategic health therapies.

You are welcome to try or order their flagship products ProArgi9 & Mistica through our office or you can order online at www.eti.mysynergy.net

ProArgi-9 contains 5,000 mg (5 grams) of elemental pharmaceutical grade Arginine in the form best metabolized.
• Highest grade pharmaceutical manufacturing standards
• Anti-aging formula
• Supports healthy blood sugar levels (low glycemic)
• Great tasting
• Travel packets available

Mistica
We’ve all heard of free radicals and the negative effects they can have on our health. Free radicals occur everywhere in our environment, including our food and in the air we breathe. The açai berry and the other fruits found in Mistica are natural sources of anthocyanins. An extremely potent type of antioxidant, anthocyanins are the pigments found in berries, red grapes, and other healthful foods. These compounds offer numerous health benefits, including the ability to support the circulatory and cardiovascular systems.

In addition to powerful antioxidants, açai also contains essential fatty acids, amino acids, and plant sterols, which are compounds that resemble cholesterol. Sterols help maintain proper cholesterol levels that are already in the normal range. They are also useful in maintaining a healthy prostate and in aiding the immune system.

A daily serving of Mistica in your nutritional regime may help to enhance vitality and energy, while guarding against the ravages of free radical damage.

Potential Benefits:
• Antioxidants to help counter cell inflammation and premature aging.
• Anthocyanins to support the cardiovascular system.
• Essential fatty acids to aid in digestive tract function.
• Phytosterols to help maintain normal cholesterol levels.
• Amino acids for enhanced muscle activity.

As always my staff and I are committed to providing you with the best quality supplements available for your convenience & value. You have a myriad of choices. We encourage everyone to decide what is best for you. We will have some exciting announcements & introductions to share with everyone this upcoming fall season.

As always, It’s your time!

L-Arginine

Historically I have felt I had to be involved in the sale of l-arginine because so many companies were inconsistent in what they offered the consumer. I have been involved in the planning and production of all the ForMor products containing l-arginine and I am compensated for this work. I like to send out an email defining this every time I get the feeling that some people may not know this association.

We have received many recent remarks of praise from other companies who have l-arginine products. I am very proud of what we are doing. I’m very proud of our product.

The following is a response from our webmaster which you might find helpful.

My name is Peggy Prendergast and I manage Dr. Joe's E-News lists and the EMMC website. I'm going to forward your message to Dr. Prendergast to address however he chooses, but I wanted to address one your concerns as I have tried to make Dr. Prendergast's affiliation to ForMor clear.

If you scroll down to the bottom of this message, just above the bolded information about how to remove yourself from this list, is a sentence about Dr. Joe and ForMor. That footer goes out in every one of Dr. Joe's newsletters. Also, the announcement of Dr. Joe's association with ForMor was linked from the EMMC home page (in the lower left, "In The News") but was removed due to other news occurring. However, the Press page still lists the announcement, it is the 8th in the list.

Vitamin D and L-Arginine

The American Journal of Clinical Nutrition, Vol, 85, 1, 6-18, January 2007 has come out with an exceptionally important article on vitamin D forward to me by a good friend of mine, Clay Stringer. One of the authors of this study I consider to be a good friend of mine too, although I haven’t seen him in so long he probably has no memory of me, Robert Heaney, MD.

They are assuring us all that the new levels of D everyone is using is safe. In fact, they are now suggesting that we all take 10,000 IU of Vitamin D Daily, twice what I am suggesting now after we do the “Stoss” therapy.

Between the use of the D and the l-arginine which I have promoted in ever increasing amounts, my professional life has become an absolute joy. You can’t imagine how delightful it is to visit people who are steadily getting healthy rather than just coping with disease.

Drug Eluting Stents - A Follow Up

The eNews below was sent to the people who have been patients in the Office. I seem to have not expressed myself well because a number of responses felt that I was damning all the therapies mentioned.

I was not.

In fact, all the therapies mentioned have been proven to be of some worth to prevent primary and recurrent blood clots in the arteries. We have little experience with these new stents but wished to warn anyone that this new therapy with the coated stents seem to have such a major problem, they are no longer use in Europe.

It appears that these stents release the coating into the tissue around the stent, not just the central part of the stent, causing clotting in nearby blood vessels. The problem is with the stent and even though these excellent therapies were applied, they were not able to overcome the toxic substance eluted from the stent.

Lastly, I was asked if I was “now saying that l-arginine is not safe.” This link is to our Web Site that contains 39 pages of material that indicates l-arginine is unparalleled in preventing heart attacks and strokes.

The new drug eluting stents the world has been awaiting have run into unanticipated problems. Clots are occurring in the stents themselves and the collateral vessels that ordinarily would shunt blood around the larger clogged artery with the stent inside.

This appears to be an intrinsic flaw in the stent and has nothing to do with actions of the patient. The medications that have used to prevent clotting are failing everywhere. These medications are statins, l-arginine, aspirin, Plavix and most important of all aerobic exercise.

It appears that the exercise will bring out progenitor cells to line the arteries, especially the damaged areas where the stents were placed. This advice was never needed with the prior stents so no one is quite sure if it will do the job now.